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Poster Presntation, The Lancet Neurology Conference Preclinical neurodegenerative disease: towards prevention and early diagnosis Oct 19-21, 2016, Park Plaza Riverbank, London, UK

The SLC22A5 gene is located on chromosome 5q31.1 and is composed of 11 exons that generate two alternatively spliced mRNAs that encode proteins of 581 amino acids (isoform a) and 557 amino acids (isoform b)

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These symptoms can even appear even before a full-blown deficiency develops ( While fatigue and irritability may be some of the first symptoms to appear, they typically resolve after just a few days of adequate intake or within 24 hours of high-dose supplementation ( Summary Signs of fatigue and poor mood can appear even with low-to-normal levels of vitamin C, but they quickly turn around with adequate vitamin C intake