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The synthetic TB-500 represents the active segment of T4, focusing on a specific portion believed to drive its biological activity

Disruption of the autophagic pathway occurs when mitochondria are damaged, leading to an accumulation of -syn and promoting aggregate formation

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Furthermore, the differential metabolite of walengzi, N6-isopentenyladenosine, induces S/G2 arrest and apoptosis in thyroid cancer TPC-1 cells (Sun et al., 2017)

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