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After seven days of treatment, increases persisted in substantia nigra (both compacta and reticulata), lateral caudate, accumbens nucleus, and superior olive

Vascular issues Though rare, overuse of therapeutic B12 may lead to vascular events: Clots in deep veins Swelling in the legs Risk of pulmonary complications in sensitive groups Tabular View for Quick Recap You should report symptoms early to stop things from getting worse

The differences between these two will be talked about later

Example: Your protocol calls for a 250mcg dose

Thats a very tiny amount

This is the practical reason a reader who is nervous about small-volume accuracy might prefer the 50 mg protocol the trade-off being that each vial carries fewer total doses, as the supply math shows next