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PM: design, collection of data, data analysis, and final approval of manuscript

These results indicated that reduced heteroplasmy leads to greater upregulation of mtDNA translation and that levels of heteroplasmy correlate to mtDNA copy number, glucose metabolism, and mitochondrial functions when normalized to mtDNA:nDNA copy number

[PMC free article: PMC2173981] [PubMed: 12486113] 353

10.1007/s00210-024-03617-3

However, enhanced expression of GGT and MRP1, which are associated with the -glutamyl cycle, has been observed in damaged myocardium [33, 34, 51, 52]

Inflammasome activation of cardiac fibroblasts is essential for myocardial ischemia/reperfusion injury