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Endocannabinoid System and the Neuroendocrine Regulation of Energy Metabolism Endocannabinoid System and the Hypothalamus Adipose Tissue Axis in Obesity Obesity is a major health issue (Kelly et al., 2008) and no country succeeded in decreasing the number of obese individuals in the last decades, indicating the limitation of the worldwide public health policies (Burgio et al., 2015)

Elevated levels of TMAO have been controversially associated with an increased risk of cardiovascular disease in some epidemiological studies

10.1016/j.neuropharm.2016.03.055 Neuropharmacology 112 EgertovM.CravattB

Digestive Enzymes : facilitate the breakdown and utilization of vital macronutrients (carbs, proteins, fats)

doi:10.1152/ajpendo.00277.2001 Spiering, Barry A et al

Thus, the causal relationship among ER stress induction, pERK1/2, and autophagy activation was examined using MAPK/ERK and ER stress inhibitors, namely U0126 and 4-PBA