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It is important to take into consideration that many phytoconstituents have a low bioavailability when they are consumed orally as the body considered them xenobiotics (Kara et al., 2017) and, thus, may produce a significantly different result as that demonstrated from in vitro studies
Besides, FRO3 and FRO8, present in the mitochondrial membrane, also regulate Fe homeostasis in mitochondria (Jeong and Connolly, 2009)
doi: 10.1073/pnas.1702739114, [DOI] [PMC free article] [PubMed] [Google Scholar] Mayhew C
Treatment and management of cognitive dysfunction in patients with multiple sclerosis
Analytical Challenges in the Detection of Peptide Hormones for Anti-Doping Purposes
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