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Grey lines represent each individual participant, and the black line represents the mean values

Blood 139:21302144 Mastellos DC, Hajishengallis G, Lambris JD (2024) A guide to complement biology, pathology and therapeutic opportunity

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Consistent with expectations, bona fide p53 targets including HDM2 and CDKN1A were among the most highly up-regulated genes in Control cells, whereas genes known to be negatively regulated by p53, such as E2F2 , were strongly down-regulated (el-Deiry et al, 1993