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The switch from an immunologically centered pathogenetic hypothesis to a metabolic-based theory would represent a groundbreaking change in the setting of vitiligo for its therapeutic implications

[DOI] [PMC free article] [PubMed] [Google Scholar] 7.Certo M, Llibre A, Lee W, Mauro C

Vitamin B12 deficiency is one of the most common nutrient deficiencies in the world, especially for vegetarians, vegans and people with health conditions such as Crohns Disease or Celiac Disease which makes it hard to absorb nutrients

It has been shown that once activated, plasmin activates matrix metalloproteinases that allows for macrophage movement through the extracellular matrix [94]

Roe ND, He EY, Wu Z, Ren J (2013) Folic acid reverses nitric oxide synthase uncoupling and prevents cardiac dysfunction in insulin resistance: role of Ca2+/calmodulin-activated protein kinase II

39 ZhangY.JiW.QinH.ChenZ.ZhouY.ZhouZ.et al