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This decline leads to visible signs of aging, such as dark spots, uneven skin tone, and wrinkles

GSH functions as a neurotransmitter and neuromodulator as it contains binding sites for putative receptors, most likely glutamate receptors (52)

10.1016/j.scr.2009.12.003 49

For these reasons, quiescent stem cells reside in a low oxygen niche favoring glycolysis over mitochondrial respiration and express high levels of antioxidant systems[18,31]

Recent advances in molecular imaging further support this propagation pattern