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Furthermore, acyl-ghrelin was found to bind to the ghrelin receptor by effectively utilizing this bifurcated pocket. In addition to promoting GH secretion (Kojima et al., 1999), the ghrelin-ghrelin receptor system participates in appetite stimulation, body temperature regulation, and cardioprotection (Nakazato et al., 2001

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However I could not find any evidence-based info or research on HPC

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The nasal respiratory mucosa is characterised by a lining of pseudostratified, ciliated columnar epithelial cells and goblet cells, both of which play a critical role in intranasal drug delivery