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Finally, the sample size was very small

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And in a mouse model with a genetic deletion of GPX4, MK-4 showed a protective effect on tissues (Mishima et al., 2022)

Desulfovibrionales have genes for sulfate reduction that reduce sulfate to hydrogen sulfide, which results in enhancing farnesoid X receptor (FXR) in HepG2 cells and followed by CYP7A1 inhibition ( Further evidence linking drug metabolism and gut microbiome is research investigating how tacrolimus (TAC) pharmacokinetics were affected by gut microbiome using in vivo mice models