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GS, expressed specifically in astrocytes, converts glutamate (which is synthesized in astrocytes from glucose) to biologically inactive glutamine, which is exported to extracellular space by Na + -dependent neutral amino acid transporters SNAT3 and SNAT5 (SLC38A3 and SLC38A5) and imported into neurons by SNAT1 and SNAT2 (SLC38A1 and SLC38A2) 434,435

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The regeneration of glutathione (GSH) from its oxidized form (GSSG) is a critical cellular process for maintaining redox balance

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Nature 440:944948 Anderson EJ, Lustig ME, Boyle KE et al (2009) Mitochondrial H 2 O 2 emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans

In another experiment, rats were given a combination of LC and lipoic acid to see how it affected age-dependent apoptosis in skeletal muscle fibers ( Table 1 ) (Tamilselvan et al., 2007)