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Because transdermal administration necessitates passing through the hydrophobic/lipophilic SC, absorption in the deep aqueous layers, and then passage into the systemic circulation, these substances also need to have a moderate lipophilicity/hydrophilicity balance (logP = 15) [73,150,153]

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Treatment with hesperidin significantly reduced neutrophil infiltration, edema, colon shortening, and macro and microscopic damages induced by intracolonic administration of acetic acid in mice [166]