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Tirzepatide is commonly researched as a once-weekly peptide due to its extended activity profile

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The salt and detergent concentrations were lowered further by making a 2 dilution (75 mM NaCl, 20 mM TrisHCl 7.5, 0.01% DDM, 0.001% CHS), while supplementing with choline chloride to keep the concentration 5 mM, and adding 8 ml to flow through the column

And the answer has a bit of nuance

[DOI] [PMC free article] [PubMed] [Google Scholar] 105.Vidal-Casariego A., Burgos-Pelez R., Martnez-Faedo C