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In high-fructose cultured human podocytes (HPCs), the upregulation of Sp1 promotes the expression of HDAC4 and leads to the disappearance of the foot process and the intensification of the inflammatory response

Others include GLP-1 agonists (used for blood sugar management), and treatments for osteoporosis and migraines

Overall, these findings provide compelling evidence supporting the potential value of directly targeting alpha-synuclein as a therapeutic strategy