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This syndrome occurs rarely in dogs with liver cirrhosis and nodular hyperplasia and whose pathogenesis is poorly understood

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10.1007/s00280-010-1470-2 111 KanaiM.OtsukaY.OtsukaK.SatoM.NishimuraT.MoriY.et al (2013)

It is important to note that most of these effects have been observed in animal studies, and human clinical trials are currently very limited

Tekautz et al
