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TSH triggers the release of THs, mainly the prohormone thyroxine (T 4 ) and, to a lesser extent, the active form triiodothyronine (T 3 ), by the thyroid gland

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This process involves the sequestration and degradation of cellular components in a double-membrane structure called the autophagosome, which fuses with lysosomes leading to the degradation of the aggregates (Takahashi et al

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This results in the formation of toxic compounds called advanced glycation end products , or AGEs