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A meta-analysis of blood GSH responses found no significant pooled increase in erythrocyte or plasma GSH after supplementation, with high heterogeneity and reporting concerns, underscoring bioavailability and measurement challenges

Samples must be collected within two to four hours post-administration to capture measurable concentrations, and immediate processing (centrifugation, plasma separation, freezing at 80C) is essential to prevent ex vivo degradation

We appreciate the funding support from National Heart Blood Lung Institute at the National Institutes of Health (NIH) award 1R15HL143545-01A1

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EMBO J 2001, 20: 51975206

[DOI] [PMC free article] [PubMed] [Google Scholar] 57.Di Filippo M., Chisserini D., Tozzi A., Picconi B., Calabresi P