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Nanotechnology 27 , 465601 (2016)

Ferroptosis and exposure to metals/pesticides amplify oxidative injury via Fenton chemistry, glutathione depletion, and GPX4 inhibition

However, the use of animal models is expensive, requires a lot of time and expertise, has low throughput potential, poses ethical issues, but most importantly, these models often do not correlate to human systems (Barr-Sinoussi and Montagutelli 2015)

[DOI] [PMC free article] [PubMed] [Google Scholar] [38].Piattini F, Matsushita M, Muri J, et al

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The observation of metal sulphides as neutral fragments in the unimolecular decomposition of bio-organic ions is relatively rare, and only one case has been very recently reported in a study of lead-binding metallothionein [122] (see below)