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The expression of NAMPT increased tumor cell proliferation, ERK-1/2 and p38 activity levels, the expression levels of metalloproteases, colony formation, and resistance to apoptosis

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This review aims to highlight the central role of OS in the pathophysiology of ALS, specifically focusing on the KEAP1-NRF2 system and its alteration in ALS, while discussing the potential applications of NRF2 activators in ALS therapy

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2024;29:394 Hollestein V, Poelmans G, Forde NJ, Beckmann CF, Ecker C, Mann C, et al