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Since AOD 9604 is daily and tirzepatide is weekly, one day per week they will overlap

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In addition to GSH, 6 studies also assessed plasma GSSG (N = 3) (Jones et al., 2002, Kretzschmar et al., 1991, Yang et al., 1995), GSH/GSSG (N = 1) (Paolisso et al., 1998) and/or tGSH (N = 3) (Andriollo-Sanchez et al., 2005, Kretzschmar et al., 1991, Nuttall et al., 1998) levels

Other suitable substitutions within the MMP-29 catalytic domain are encompassed by the present invention and are referenced elsewhere herein

16,326 In conditions of nutrient excess, as seen in T2DM, insulin resistance blunts insulin-mediated nutrient and energy responses, impairing nerve metabolism and bioenergetic failure

J Neurosci 32, 89408951, doi: 10.1523/JNEUROSCI.0026-12.2012 (2012)