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NCOA4, nuclear receptor coactivator 4
Since D2HG and L2HG are indistinguishable in standard LC-MS, to determine which 2HG enantiomer(s) is affected, we adapted a chiral N-(p-toluenesulfonyl)-L-phenylalanyl chloride (TSPC) derivation followed by liquid chromatography with tandem mass spectrometry (LC-MS/MS) analysis 24,40
Retention time was 8.7 min for SAH and 13.6 min for SAM
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The forced swim test (FST) and Morris water maze test were developed for the evaluation of depression-like ailments and spatial memory in rats and mice, respectively (Samad et al
Cochrane Database Syst Rev 2009
