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Quasi-closed system A system is closed if there is no interaction with the external environment

In addition, TXN acts as an antioxidant by facilitating the reduction of oxidised proteins through cysteine-thiol-disulfide bond exchange [81, 82]

Some of these aldehydes such as 4-hydroxynonenal, 4-hydroxyhexenal, and malonaldehyde are highly reactive and may be considered as second toxic messengers which will cause the cross-linking polymerization of life macromolecules such as proteins and nucleic acids, and affect the activities of mitochondrial respiratory chain complexes and key enzymes in mitochondria, resulting in cell death (Esterbauer et al., 1991) (Figure 3)

Proceedings of the National Academy of Sciences of the United States of America 61, 748-755CrossRefGoogle ScholarPubMed 39Maines, M.D

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