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[DOI] [PMC free article] [PubMed] [Google Scholar] Zechmann B, Stumpe M, Mauch F

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Gomez D, Logan JK, Tang C, Liao Z, Lee JJ, Heymach JV, Swisher SG , Welsh JW, Zhang J, Lin SH

Absorption into the CNS after intranasal administration has been postulated to occur via the olfactory and trigeminal neuronal pathways (intraneuronal) and diffusion across mucosal barrier and olfactory plate (extraneuronal), depending on the size, polarity, and odorant nature

above 40C, phospholipid thermal motion increases, causing vesicle breakdown and ingredient leakage