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Description
Moore CD, Thacker EE, Larimore J, Gaston D, Underwood A, Kearns B, Patterson SI, Jackson T, et al

We do have some information to go off of, though

Estradiol mediates colonic epithelial protection in aged mice after stroke and is associated with shifts in the gut microbiome

Transdermal drug delivery. Nature Biotechnology , 2008.

Is KLOW safe to use long-term

Although less common, minor side effects are redness or swelling at the injection site
