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10.3389/fonc.2023.1089115 122

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However, its successful application will require further elucidation of TREM biology in humans, regarding the cell-type specificity of TREM expression (e.g., in astrocytes, oligodendrocytes, and neurons), species differences between humans and mice, immature metabolic and mitochondrial features of in vitro culture (e.g., BV and iPSC-derived cells), early-onset or late-onset, and the temporal dynamics of disease progression with senescence

Nishikawa, K., Osawa, Y

The covalent CDK7 inhibitor THZ1 was found to be highly effective against SCLC in a combination in vivo / in vitro study by suppressing the expression of proto-oncogenes such as c-Myc , SRY-box transcription factor 2 ( SOX2 ), and nuclear factor I B (NFIB)