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These findings position the compound as a valuable research tool for investigating whether NNMT modulation influences age-associated metabolic changes in mammalian aging models

Animal studies demonstrate that chronic tesofensine treatment produces sustained weight loss even as tolerance to the hypophagic effect gradually develops, indicating additional factors beyond appetite regulation contribute to maintaining maximal weight loss

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Food intake inhibition and reduction in body weight gain in lean and obese rodents treated with GW438014A, a potent and selective NPY-Y5 receptor antagonist

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