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Indeed, synergy between levodopa and natural bioactives already has clinical precedent: istradefylline, modeled after caffeine's natural adenosine A 2 A antagonism, is used to reduce levodopa's off periods, while green tea's (+)catechin demonstrates COMT inhibition, potentially enhancing levodopa's duration of effect [4, 116, 118]

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10.1016/S0893-133X(02)00306-8 Pubmed Abstract CrossRef Google Scholar View reference in article 97

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