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87 Notably, GSH protection against antibiotics did not require the AcrAB pump but failed in cells lacking the TolC channel, 88 suggesting that TolC-dependent pumps are involved

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In other words, these oxidised proteins were not degraded by proteasome rapid enough to avoid apoptotic death resulting from the build up of these proteins

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Together, our findings demonstrate that the first week of neuronal differentiation represents a critical period of proteomic and metabolic reprogramming