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The primary functions of COX-1 are to maintain the integrity of the gastric mucosa and to control gastric blood flow and acid secretion, whereas COX-2 enzyme activated during an inflammatory response upregulates prostaglandin synthesis at the location of ulceration (Mizuno et al

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Innov Pharm Pharmacother 7:714 Afzal M, Khan NA, Ghufran A, Iqbal A, Inamuddin M (2004) Diuretic and nephroprotective effect of Jawarish Zarooni Sada - A polyherbal Unani formulation