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These include immune checkpoint inhibitors (ICIs) targeting PD-1/PD-L1, such as pembrolizumab and nivolumab, which have exhibited encouraging results in early clinical trials [146, 147]

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Folic acid should be used with extreme caution in patients with undiagnosed anemia

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Sections were then blocked for non-specific binding with 10% serum in PBS for 60 min at room temperature, and then incubated with primary antibody in blocking solution O/N at 4 C

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