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Pairing glutathione with Vitamin C actively recycles it into its reduced form, extending its antioxidant effect at the cellular level

This structural transition significantly enhances the targeting affinity and efficiency of ANAs against MRSA

C 76 , 743751 (2017)

biochemically, there is intracellular glutathione (GSH) depletion and decreased activity of glutathione peroxidase 4 (GPX4), lipid peroxides cannot be metabolized by the GPX4-catalyzed reduction reaction, and Fe 2+ oxidizes lipids in a Fenton-like manner, resulting in a large amount of ROS, which promotes ferroptosis 3,6

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