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Extracellular mtDNA can act as a damage-associated molecular pattern (DAMP), triggering the activation of innate immune receptors such as toll-like receptors (TLRs) and inducing the production of type I interferons (IFNs) [131]

Melasma appears as brown or grey patches, commonly on the cheeks and forehead

J Inorg Biochem 2019;195:1119

This way, animal and plant-based protein diets and healthy fat have a lower energy footprint and less environmental impact 43,44

[DOI] [PMC free article] [PubMed] [Google Scholar] 365.Huang Y, Liu J, He J, Hu Z, Tan F, Zhu X, et al