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K., Dumala, N., Chakravarth, G., Venkateswarlu, K., Gutti, G., Yadagiri G., Duguluri S., Rai S

Proteomics (2010) 10(3):496505

Iron typically binds to transferrin (TF) in a Fe 3+ form, thereby entering cells via transferrin receptor (TFRC) [43], then get reduced to Fe 2+ by Six-Transmembrane Epithelial Antigen of Prostate (STEAP3) metal reductase in endosome

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During PARthanatos, energy depletion and PAR polymer accumulation increase mitochondrial membrane permeability, releasing AIF into the cytoplasm