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A well-known method of repressing transcription is methylation close to gene promoters

Nygrd O, Refsum H, Ueland PM, and Vollset SE (1998)

We previously reported that reduced levels of activated hepatocyte growth factor and the c-Met receptor tyrosine kinaseboth of which are vital for maintaining cellular redox balancecombined with increased expression of GJ proteins in hepsin-deficient mice

While existing evidence confirms the association between CIH and the PD-1/PD-L1 pathway, critical gaps remain: the specific molecular mechanisms of PD-1/PD-L1 expression mediated by different cell types and the dose-effect relationship between CIH severity and PD-L1 expression

Burk RF, Hill KE, Motley AK, Austin LM, Norsworthy BK (2006) Deletion of selenoprotein P upregulates urinary selenium excretion and depresses whole-body selenium content

doi: 10.1016/j.euroneuro.2018.12.015 53