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Cancer cells are known to have altered metabolism and increasing metabolic stress through nutrient deficiencies could be a suitable addition to current cancer therapies

Table II [i] MASLD metabolic dysfunction-associated steatotic liver disease, ROS reactive oxygen species, MDA malondialdehyde, 4-HNE 4-hydroxynonenal, 8-OHdG 8-hydroxy-2-deoxyguanosine, ox-LDL oxidized low-density lipoprotein, NOX NADPH oxidase, CYP2E1 cytochrome P450 2E1, TGF- transforming growth factor , UCP2 uncoupling protein 2

The reduction of mitochondrial function with age is commonly acknowledged

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Three clinical stages (phases) of acetaminophen-induced liver injury have been described