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In sarcoidosis patients, IFN- may exert anti-apoptotic effects on macrophages by inducing the expression of the cyclin-dependent kinase inhibitor p21/Waf1, thereby contributing to the persistence of lung inflammation [122]

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Workers with prolonged exposure to 4-aminobiphenyl exhibit significantly higher bladder cancer rates compared to the general population (Tao et al., 2013

67 Immune-related lncRNAs, such as DiGeorge syndrome critical region gene 5, are associated with immune and stromal cell infiltration, highlighting their role in regulating the tumor immune response

Such an imbalance is responsible for severe damage to essential biomolecules, such as lipids (lipid peroxidation), proteins (oxidation and inactivation), and DNA (strand breakage and mutations), which is associated with the pathogenesis of numerous diseases, including cancer, neurodegenerative diseases, cardiovascular diseases, and the aging process [28]

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