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Therefore, small molecules may cause off-target effects in vivo despite its in vitro efficacy

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however, RB1 loss leads to excessive E2F1 activation, resulting in uncontrolled BNIP3 expression and autophagic cell death under hypoxic or nutrient-deprived conditions

The relative risks of various nicotine products: how differences in nicotine concentration, absorption rates, and presence of contaminants impact their safety [37:00]