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Some people report positive results with other treatments, but those with true pernicious anemia are unlikely to benefit at all

187 (15), 40434060.e30

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Food and Drug Administration (FDA) panel of experts in 2009 recommended that the maximum single dose of acetaminophen in adults be lowered from 1000 to 650 mg

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This argument is plausible it reflects a well-documented problem in drug development where unpatentable compounds struggle to attract industry funding regardless of their scientific merit but it should be noted that this explanation, while widely discussed, has not been formally established in the published literature as the primary reason for the evidence gap