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Pharmaceutical and/ or dietetic compositions, containing as their active ingredient the combination according to claims 1-3, and at least one pharmaceutically acceptable excipient
Discordances concentrate in the mixed-GT cohort

Low urinary pH predisposes for uric acid precipitation since the pKa of uric acid is 5.7, therefore the solubility of uric acid decreases with low pH, and thus increasing the risk of kidney stones (8, 44)

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Thus, whether TMAO is an atherogenic factor responsible for the development and progression of cardiovascular disease, or simply a marker of an underlined pathology, remains unclear [85]
