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SIRT5 regulates the NRF2/HO-1 pathway in a ROS-dependent manner to inhibit cisplatin (CDDP)-induced DNA damage, thereby promoting CDDP resistance in ovarian cancer (OC) [77]

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Additionally, compounds such as PL 1-3 (Li et al., 2023) and Empagliflozin (Long et al., 2024) have garnered attention for their ability to upregulate SIRT1, enhance mitochondrial function, and reduce oxidative stress and senescence markers, thereby mitigating the progression of liver diseases such as MASLD

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CSF studies sometimes show oligoclonal bands [19,20,21,22]

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10.1016/j.ntm.2025.100075 55 EzhumalaiN.NandhagopalM.RajendiranN

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As mentioned above, Nrf2 is a protective factor for viral hepatitis, but it may contribute to the occurrence and progress of HCC

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Plants activate a highly developed immune system when subjected to biotic stress, starting with the waxy, thick cuticle and unique trichomes on their surfaces, which effectively prevent pathogens or insects from attaching to the plant (Moustafa-Farag et al., 2020

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