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doi: 10.1038/s41581-020-0267-8 [DOI] [PMC free article] [PubMed] [Google Scholar] 2

Reducing LDL-C levels through lifestyle changes or therapy is critical not only for ASCVD prevention but also for lowering the risk of ASCVD events

[DOI] [PMC free article] [PubMed] [Google Scholar] Schellekens AF, Mulders PC, Ellenbroek B, et al

After positive results from the Veterans Affairs HDL-C Intervention trial (VA-HIT) trial, showing a 22% reduction in ASCVD with gemfibrozil (1,200 mg/day) in the 1990s [8], major fibrate trials, including the Lower Extremity Arterial Disease Event Reduction (LEADER) [5], Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) [6], and Action to Control Cardiovascular Risk in Diabetes (ACCORD)-Lipid [7] in the 2000s, failed to demonstrate ASCVD prevention with fibrates

Ginsenoside Rg1 ameliorates Alzheimers disease pathology via restoring mitophagy