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[DOI] [PMC free article] [PubMed] [Google Scholar] 37.Nyengaard JR

People with deeper skin tones may see more subtle or slower changes

Unidentified environmental factors in the interplay with susceptibility genes trigger events causing inflammatory demyelination, axonal injury, and neurodegeneration

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Additionally, melatonin may modulate the hyperphosphorylation of the microtubule-associated tau protein, a process leading to the formation of NFTs characteristic of AD [32]

Of these factors, the most important is CD59, a potent inhibitor of membrane attack complex that helps to prevent intravascular hemolysis of red cells by complement