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and methylphenyltetrahydropyridine, which inhibits complex I in the respiratory chain (200)

While several subtype-specific therapeutic approaches have been identified for SCLC 36,37,38,39,40,41 , recent evidence suggests that SCLC subtype intratumoral heterogeneity may evolve as a consequence of subtype plasticity 5 highlighting the need to devise therapies targeting SCLC plasticity rather than isolated molecular subtypes

Background The current standard neoadjuvant therapy for HER2-positive early breast cancer combines trastuzumab (H) and pertuzumab (P) with multi-agent chemotherapy

Funding This work was funded by Dr Reddys Laboratories Ltd

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Desipramine and imipramine, both tricyclic antidepressants, can reversibly inhibit the inward current induced by the nAChR agonist dimethylphenylpiperazine iodide (DMPP), and their inhibitory effects are independent of the agonist concentration