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Role of free radicals and catalytic metal ions in human disease: an overview

Historical background of RNA-based therapeutics Significant advancements in gene sequencing technology have been made after the completion of the human genome project in 2003, which deepened our understanding of genetic causes for different diseases (Goodwin et al., 2016) and paved the way for the development of RNA-based therapeutics, which target disease-related genes that could not be targeted by conventional drugs, small molecules or protein-based drugs (Kaczmarek et al., 2017)

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On the other hand, MITF transcription factor/oncoprotein modulates miR-146a, -221/222 cluster, and -363 expression levels ( Familial Cutaneous Melanoma The susceptibility to melanoma is commonly observed in people carrying common variants in lower risk susceptibility genes