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POTENTIAL MECHANISMS UNDERLYING THE DECLINE IN GH SECRETION WITH AGE Three hypothalamic factors regulate GH secretion: somatostatin (Somatotropin Release-Inhibiting Factor, SRIF), growth hormone-releasing hormone (GHRH), and ghrelin (11) (Figure 2)

von Bohlen und Halbach, 2003

In December 2014, they published a paper in Nature Medicine, showing that the triple agonists weight loss effects in mice exceeded those of the dual agonists
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