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GSH supports lipid abundance by repressing NRF2 activation GSH is reported to contribute to lipid homeostasis in the body through several mechanisms 13,52,53,54,55,56

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Furthermore, signal transducer and activator of transcription 3 (STAT3) can inhibit the mTOR/HIF-1 pathway by activating AMP-activated protein kinase (AMPK), leading to reduced cell proliferation and increased apoptosis (38)

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On the contrary, while it is found that mitophagy markers are elevated in failing hearts, recent studies suggest that increasing mitophagy can alleviate microvascular endothelial dysfunction to prevent heart failure from ischemia/reperfusion injury [193, 194]

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doi: 10.1016/j.cellsig.2007.11.012

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