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Once expressed, the iNOS enzyme is catalytically active and does not respond with changes in enzyme activity to changes in intracellular calcium levels as is the case for nNOS and eNOS

Cancer cells produce more spatially concentrated ROS than normal cells, which hyperactivates the cell signaling pathways required for cellular transformation and carcinogenesis (Figure 2)

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That said, some patients report subjective increases in urination after starting therapy

10.3390/antiox10050753 113