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[6,7] Stomach acid and gut proteases destroy them before they reach systemic circulation

For instance, surface grafting density of polymers such as polyethylene glycol (PEG), polyvinylpyrrolidone (PVP), or chitosan markedly influences corona formation, steric stabilization, and mucosal adhesion

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reported that over 70% of Indian adults exhibited suboptimal serum 25(OH)D levels, with disproportionately higher deficiency among women, urban poor, and lower caste groups (223)