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Folate-rich diet increased DNA methylation of genes such as p16 [114] in mouse colon and protooncogenes such as PDGF-B (platelet-derived growth factor-B), Ras (rat sarcoma), and survivin in a mouse model of gliomagenesis [115]
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The incidence of mammary gland carcinoma in male rats increased in animals treated with 10 mg/kg/day (3 times the MRHD based on AUC)
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